Native populations of Mesoamerica tribes have used hallucinogenic Psilocybe species for religious communion, divination, and healing.
Until the 1950’s the use of hallucinogenic mushroom by non-Native Americans was thought to have ceased until R. Gordon Wasson became the first Westerners to actively participate in an indigenous mushroom ceremony (using what is believed to be Psilocybe mexicana, P. caerulescens, and P. zapotecorum) and memorialized their experiences in Life magazine in 1957. In 1958, Albert Hofmann, the discoverer of LSD first reported psilocin and psilocybin as the active compound in these mushrooms
Hallucinogenic mushroom use has been reported among a number of groups spanning from central Mexico to Oaxaca, including groups of Nahua, Mixtecs, Mixe, Mazatecs, Zapotecs, and others
It should be noted that although these different strains do possess different concentrations of psilocybin and psilocin, factors such as dosage, set, and setting are arguably more determinant of the outcome of effects experienced. Read Frshminds article “Understanding and Measuring Magic Mushroom Potency” to learn more.